Impact of HOPE on Very Old DCD (>70 Years) Livers: Insights From A Belgian Bi-centeric Experience
This bi-centric Belgian study evaluated the impact of end-ischemic HOPE (Hypothermic Oxygenated Perfusion) on very old DCD liver grafts (?70 years old). Compared with static cold storage, HOPE [...]
Screening for Mitochondrial Function Before Use-Routine Liver Assessment During Hypothermic Oxygenated Perfusion Impacts Liver Utilization
Analysis of 415 DCD Maastricht III livers over an 11-year period in Switzerland showed that 249 were transplanted, with 158 performed at the study institution. One-year patient survival and [...]
Machine Perfusion as “Comfort Zone”: What Are Key Challenges of Liver Viability Assessment Today?
A review of 203 human livers perfused with NMP, including 154 transplants, revealed that despite well-established viability criteria, 11% of transplanted livers still developed non-anastomotic [...]
Hypothermic oxygenated perfusion protects from mitochondrial injury before liver transplantation
This article investigates the role of Hypothermic Oxygenated Machine Perfusion (HOPE) in preventing mitochondrial injury and optimizing liver function before transplantation. The study compares [...]
Beneficial effects of end-ischemic oxygenated machine perfusion preservation for split-liver transplantation in recovering graft function and reducing ischemia–reperfusion injury
This study investigates the impact of end-ischemic Hypothermic Oxygenated Machine Perfusion (HOPE) on split-liver transplantation using a porcine model. The research highlights how HOPE helps [...]
Impact of Machine Perfusion on the Immune Response After Liver Transplantation – A Primary Treatment or Just a Delivery Tool
This article reviews the role of Machine Perfusion, particularly HOPE in modulating the immune response following liver transplantation. The study examines how ischemia-reperfusion injury (IRI) [...]
Improved outcomes after hypothermic oxygenated machine perfusion in liver transplantation-Long-term follow-up of a multicenter randomized controlled trial
This multicenter randomized controlled trial assessed the long-term outcomes of hypothermic oxygenated machine perfusion (HOPE) in liver transplantation using extended criteria donor (ECD) [...]
Protective mechanisms and current clinical evidence of hypothermic oxygenated machine perfusion (HOPE) in preventing post-transplant cholangiopathy
This article explores the protective mechanisms and current clinical evidence of Hypothermic Oxygenated Machine Perfusion (HOPE) in preventing post-transplant cholangiopathy, particularly in [...]
