The article compares liver transplants using circulatory death donors (DCD) with prolonged warm ischemia time to brain-dead donors (DBD). It finds that using normothermic regional perfusion (A-NRP) and hypothermic oxygenated machine perfusion (D-HOPE) improves graft function and reduces complications like ischemic cholangiopathy, resulting in outcomes similar to DBD transplants, despite longer warm ischemia times.
Patrono D, Zanierato M, Vergano M, et al. Normothermic Regional Perfusion and Hypothermic Oxygenated Machine Perfusion for Livers Donated After Controlled Circulatory Death With Prolonged Warm Ischemia Time: A Matched Comparison With Livers From Brain-Dead Donors. Transpl Int. 2022;35:10390. Published 2022 Apr 22. doi:10.3389/ti.2022.10390
