This article investigates the role of Hypothermic Oxygenated Machine Perfusion (HOPE) in preventing mitochondrial injury and optimizing liver function before transplantation. The study compares HOPE with normothermic perfusion and explores how cold oxygenation during HOPE preserves mitochondrial integrity and reduces ischemia-reperfusion injury (IRI). Additionally, the research highlights how mitochondrial markers, such as FMN and NADH, can be used to assess graft viability before transplantation.
A. Schlegel, X. Muller, M. Mueller, A. Stepanova, P. Kron, O. de Rougemont, P. Muiesan, P.A. Clavien, A. Galkin, D. Meierhofer, P. Dutkowski. EBioMedicine. (2020); Oct;60:103014. doi: 10.1016/j.ebiom.2020.103014. PMID: 32979838. PMCID: PMC7519249
