This study investigates the impact of end-ischemic Hypothermic Oxygenated Machine Perfusion (HOPE) on split-liver transplantation using a porcine model. The research highlights how HOPE helps recover liver function and mitigates ischemia-reperfusion injury (IRI), making it a viable strategy to optimize marginal grafts, such as split-liver grafts. The study compares cold storage (CS) to a combination of CS followed by 2 hours of HOPE, showing that HOPE improves biochemical markers, reduces inflammation, and enhances histological outcomes post-transplantation.
D. Ishii, N. Matsuno, M. Gochi, H. Iwata, T. Shonaka, Y. Nishikawa, H. Obara, H. Yokoo, H. Furukawa Sci Rep (2021); 11, 22608. doi:10.1038/s41598-021-01467-0. PMCID: PMC8604979 PMID: 34799598
